Scientists Have Analyzed First Ancient Human DNA From Southeast Asia

Field workers excavate ancient human remains at Man Bac, Vietnam.

Field workers excavate ancient human remains at Man Bac, Vietnam, in 2007. DNA from skeletons at this site was included in the current study. (Image: Lorna Tilley via Australian National University)

The first whole-genome analyses of ancient human DNA from Southeast Asia reveal that there were at least three major waves of human migration into the region over the last 50,000 years. The research, published online on May 17 in Science, complements what is known from archaeological, historical, and linguistic studies of Southeast Asia, defined as the area east of India and south of China.

The work illuminates another critical portion of the story of ancient population dynamics around the world, joining numerous ancient-DNA studies of Europe, as well as burgeoning research from the Near East, Central Asia, Pacific Islands, and Africa. Mark Lipson, from the Harvard Medical School and the first author of the study, said:

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DNA from Southeast Asians from 4,100 to 1,700 years ago

An international team led by researchers at HMS and the University of Vienna extracted and analyzed ancient human DNA from the remains of 18 people who lived between about 4,100 and 1,700 years ago in what are now Vietnam, Thailand, Myanmar, and Cambodia. The team found that the first migration took place about 45,000 years ago, bringing in people who became hunter-gatherers.

The team of researchers extracted and analyzed ancient human DNA from the remains of 18 people who lived between about 4,100 and 1,700 years ago.
The team of researchers extracted and analyzed ancient human DNA from the remains of 18 people who lived between about 4,100 and 1,700 years ago. (Image: Pablo Utrilla via Dreamstime)

Then, during the Neolithic Period around 4,500 years ago, there was a large-scale influx of people from China who introduced farming practices to Southeast Asia and mixed with the local hunter-gatherers.

People today with this ancestry mix tend to speak Austroasiatic languages, leading the researchers to propose that the farmers who came from the north were early Austroasiatic speakers. Co-senior author Ron Pinhasi of the University of Vienna said:

Southeast Asia migrations out of China in the Bronze Age

The research revealed that subsequent waves of migration during the Bronze Age, again from China, arrived in Myanmar about 3,000 years ago, in Vietnam about 2,000 years ago, and in Thailand within the last 1,000 years. These movements introduced ancestry types that are today associated with speakers of different languages.

The identification of three ancestral populations — hunter-gatherers, first farmers, and Bronze Age migrants — echoes a pattern first uncovered in ancient DNA studies of Europeans, but with at least one major difference: Much of the ancestral diversity in Europe has faded over time as populations mingled, while Southeast Asian populations have retained far more variation.

Reproduction of a prehistoric cave painting showing a hunter and deer.
Three ancestral populations were identified, including hunter-gatherers. (Image: Roxana Gonzalez via Dreamstime)

Reich, professor of genetics at HMS and co-senior author of the study, explained:

Reich hypothesizes that the high diversity of Southeast Asia today can be partly explained by the fact that farmers arrived much more recently than in Europe — around 4,500 years ago compared with 8,000 years ago — leaving less time for populations to mix and genetic variation to even out.

The new findings make it clear that the multiple waves of migration, each of which occurred during a key transition period of Southeast Asian history, shaped the genetics of the region to a remarkable extent. Reich said:

Also unexpected were the linguistic implications raised by analyses of the ancestry of people in western Indonesia, Reich added:

Additional samples from western Indonesia before and after 4,000 years ago should settle the question, Reich said.

Provided by: Harvard Medical School [Note: Materials may be edited for content and length.]

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