Earliest Interbreeding Event Between Ancient Human Populations Discovered

The pattern of sharing implied five episodes of interbreeding, including one that was previously unknown. (Image: via pixabay / CC0 1.0)

For three years, anthropologist Alan Rogers has attempted to solve an evolutionary puzzle. His research untangles millions of years of human evolution by analyzing DNA strands from ancient human species known as hominins. Like many evolutionary geneticists, Rogers compares hominin genomes looking for genetic patterns such as mutations and shared genes. He develops statistical methods that infer the history of ancient human populations.

Neanderthal skull from the Forbes Quarry. (Image: AquilaGib via WikiCommons)
Neanderthal skull from the Forbes Quarry. (Image: AquilaGib via WikiCommons)

In 2017, Rogers led a study that found two lineages of ancient humans, Neanderthals and Denisovans, separated much earlier than previously thought and proposed a bottleneck population size. It caused some controversy — anthropologists Mafessoni and Prüfer argued that their method for analyzing the DNA produced different results. Rogers agreed, but realized that neither method explained the genetic data very well. Rogers, professor of anthropology at the University of Utah, asked:

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The new study has solved that puzzle and in doing so, it has documented the earliest known interbreeding event between ancient human populations — a group known as the “super-archaics” in Eurasia interbred with a Neanderthal-Denisovan ancestor about 700,000 years ago.

The event was between two populations that were more distantly related than any other recorded. The authors also proposed a revised timeline for human migration out of Africa and into Eurasia. The method for analyzing ancient DNA provides a new way to look farther back into the human lineage than ever before. Rogers, the lead author of the study, said:

Out of Africa and interbreeding

The paper was published in the journal Science Advances. Rogers studied the ways in which mutations are shared among modern Africans and Europeans, and ancient Neanderthals and Denisovans. The pattern of sharing implied five episodes of interbreeding, including one that was previously unknown.

The newly discovered episode involves interbreeding over 700,000 years ago between a distantly related “super-archaic” population that separated from all other humans around 2 million years ago, and the ancestors of Neanderthals and Denisovans.

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The super-archaic and Neanderthal-Denisovan ancestor populations were more distantly related than any other pair of human populations previously known to interbreed. For example, modern humans and Neanderthals had been separated for about 750,000 years when they interbred. The super-archaics and Neanderthal-Denisovan ancestors were separated for well over a million years. Rogers said:

The authors used other clues in the genomes to estimate when the ancient human populations separated and their effective population size. They estimated the super-archaic separated into its own species about 2 million years ago. This agrees with human fossil evidence in Eurasia that is 1.85 million years old. The researchers also proposed there were three waves of human migration into Eurasia. The first was 2 million years ago when the super-archaics migrated into Eurasia and expanded into a large population.

Then 700,000 years ago, Neanderthal-Denisovan ancestors migrated into Eurasia and quickly interbred with the descendants of the super-archaics. Finally, modern humans expanded to Eurasia 50,000 years ago where we know they interbred with other ancient humans, including Neanderthals. Rogers said:

Provided by: University of Utah [Note: Materials may be edited for content and length.]

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